Mitochondrial Dysfunction in Cardiovascular Diseases: Metabolic Pathways and Potential Treatments

Abstract

Mitochondrial dysfunction in cardiovascular diseases underscores a complex interplay between metabolic pathways and cellular energetics, heralding a pivotal area in contemporary research. The intricate relationship between mitochondrial health and cardiovascular function dictates a delicate balance crucial for cardiac performance. Disruptions in mitochondrial bioenergetics, oxidative stress, and impaired calcium handling precipitate a cascade of pathological events, contributing to various cardiovascular ailments. In this context, elucidating the nuanced mechanisms of mitochondrial dysfunction unveils promising avenues for therapeutic intervention. Emerging strategies, including pharmacological agents targeting mitochondrial biogenesis, antioxidant therapy, and metabolic modulators, offer promising prospects in ameliorating mitochondrial dysfunction and mitigating cardiovascular disease burden. As research advances, unraveling the intricate nexus between mitochondrial dysfunction and cardiovascular pathophysiology promises to revolutionize therapeutic paradigms, paving the way for more effective treatments and improved clinical outcomes.